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KMID : 0606920170250030249
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Biomolecules & Therapeutics
2017 Volume.25 No. 3 p.249 ~ p.258
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Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice
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Jeon Se-Jin
Kim Bo-Seong
Ryu Byeol
Kim Eun-Jin
Lee Sun-Hee
Jang Dae-Sik
Ryu Jong-Hoon
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Abstract
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To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance task, ameliorated alternation behavior in the Y-maze, and increased exploration time in the Morris water maze task, indicating the improvement of cognitive behaviors against cholinergic dysfunction. The biflorin-induced reverse of latency in the scopolamine-treated group was attenuated by MK-801, an NMDA receptor antagonist. Biflorin also enhanced cognitive function in a naive mouse model. To understand the mechanism of biflorin for memory amelioration, we performed Western blot. Biflorin increased the activation of protein kinase C-ζ and its downstream signaling molecules in the hippocampus. These results suggest that biflorin ameliorates drug-induced memory impairment by modulation of protein kinase C-ζ signaling in mice, implying that biflorin could function as a possible therapeutic agent for the treatment of cognitive problems.
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KEYWORD
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Biflorin, N-methyl D-aspartate receptor, Cognition, Protein kinase C-ζ
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